MEZLOCILLIN

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Unlike most other extended spectrum penicillins, it is excreted by the liver, therefore it is useful for biliary tract infections, such as ascending colangitis.

MECHANISM OF ACTION

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

SUSCEPTIBLE ORGANISMS

GRAM-NEGATIVE

Bacteroides spp., including B. fragilis
Enterobacter spp.
Escherichia coli
Haemophilus influenzae
Klebsiella species
Morganella morganii
Neisseria gonorrhoeae
Proteus mirabilis
Proteus vulgaris
Providencia rettgeri
Pseudomonas spp., including P. aeruginosa
Serratia marcescens

GRAM-POSITIVE

Enterococcus faecalis
Peptococcus spp.
Peptostreptococcus spp.

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